Expand the list below for details of our Clinical Research Fellows' Projects
Dr Paul Connelly: Sex Steroids and Vascular Health
Clinical Research Fellow Dr Paul Connelly is researching the effect of sex steroids upon vascular function and physiology. A deeper understanding of the alterations in vascular pathology and outcomes in transgender people receiving gender-affirming hormone therapy could be fundamental in informing the management of cardiovascular risk in this population and more broadly advance our understanding of the role of sex and gender in vascular health and disease.
We will undertake a series of studies to carefully assess vascular phenotypes, structure and function in people utilising gender-affirming hormone therapy, which will help us understand how sex hormones influence vascular health and impact risk of cardiovascular disease.
Supervisors:
- Professor Rhian Touyz
- Professor Christian Delles
- Dr Gemma Currie
Dr Stephen Dobbin: Markers and Mediators of Angiogenesis Inhibitor-Induced Vascular and Myocardial Toxicity
Clinical Research Fellow Dr Stephen Dobbin is undertaking a prospective study in patients with cancer. The outlook for patients with cancer has improved dramatically. This is mainly due to new drugs. Vascular Endothelial Growth Factor-signalling pathway inhibitors (VSPIs) are important anti-cancer drugs. However, they cause high blood pressure and can impair heart pumping. Patients are at risk of heart failure, heart attacks, strokes and kidney failure. Sometimes the VSPI dose needs to be reduced or treatment stopped as a result and these patients do not get full anti-cancer effects.
How VSPIs cause these side-effects is not well understood. Changes to small and large blood vessels seem very important. My project is using detailed heart and blood vessel scans, blood pressure monitoring and blood tests before and during treatment with VSPIs to monitor patients receiving these medications. This will allow better understanding of how VSPIs cause high blood pressure and heart pump problems. This should help to predict who will have these problems and to know the early warning signs. This will guide the best ways to treat and prevent these side-effects. We want patients with cancer to be able to get the best treatment without unacceptable heart and blood vessel side-effects or risks.
Supervisors:
- Dr Ninian Lang
- Professor Mark Petrie
- Professor Rhian Touyz
Dr Leanne Mooney: Clonal Haematopoiesis Heart Failure
Clinical Research Fellow Dr Leanne Mooney is investigating Age-Related Clonal Haematopoiesis and Inflammation in Patients with Heart Failure via a prospective cohort study.
Supervisors:
Dr Carly Adamson: Personalising Treatment of Heart Failure using Clinical Trial Data
Clinical Research Fellow Dr Carly Adamson is looking at how we can use new statistical techniques to analyze information from patients with heart failure with the aim to help tailor care for each individual patient.
Supervisor:
Dr Su Ern Yeoh: Sodium glucose transporter inhibitor dapagliflozin versus thiazide diuretic in patients with heart failure and diuretic resistance
Clinical Research Fellow Dr Su Ern Yeoh is undertaking a multi-centre, open-label, randomised controlled clinical trial. Diuretic resistance in heart failure is difficult to treat. Current treatment guidelines for diuretic resistance involve a thiazide or thiazide-like diuretic or spironolactone in combination with a loop diuretic, but have limited efficacy in achieving adequate diuresis in these patients. Sodium glucose co-transporter-2 inhibitors (SGLT2i) have shown cardioprotective and renoprotective benefits, with a postulated role of glucose-mediated osmotic diuresis and natriuresis. Little is known about the therapeutic effect of SGLT2is in diuretic resistance. We aim to study if combination diuretic therapy with SGLT2i results in greater diuresis compared to combination diuretic therapy with thiazide diuretic in diuretic resistant heart failure patients.
Supervisors:
- Dr Ross Campbell
- Professor Mark Petrie
- Professor John McMurray
Dr Michael Freeman: Understanding myocardial-scar interactions to predict ventricular arrhythmias
Clinical Research Fellow Dr Michael Freeman is studying the interactions between scar after a heart attack and the development of dangerous abnormal heart rhythms. After a heart attack, scar in the heart muscle can disrupt the normal rhythm of the heart, putting patients at risk of collapse and sudden death. Some medications can reduce the risk bit the only way to prevent these deaths is to implant a device which can give a shock (a defibrillator). We would prefer a treatment which stopped these rhythms from happening in the first place. We know that the interaction between the scar and the heart muscle is crucial to determining when and how dangerous rhythms arise. Dr Freeman’s work will examine how this interaction could be tested objectively in patients to work out who is at high risk and why. We will look at the structure of the scar itself, but also the effect the scar has on the electrical activity. Through this we hope to develop better ways to identify those patients who really need a defibrillator and to improve treatments which modify scar-muscle interactions to reduce the occurrence of dangerous rhythms and so reduce the need for defibrillators.
Supervisors:
Dr Helen Casey: Acute insults and long-term consequences: Studies into endothelial cell function in cardiovascular diseases
Clinical Research Fellow Dr Helen Casey's PhD project is entitled "Acute insults and long-term consequences: Studies into endothelial cell function in cardiovascular diseases"
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. The vascular endothelium is a single-cell layer that lines blood vessels separating the blood and vascular smooth muscle. Endothelial function acts as an indicator of vascular health and dysfunction is seen as a precursor for CVD.
Acute insults such as sepsis, pre-eclampsia and COVID-19 which resolve are thought to be linked with increased future risk of CVD. We aim to explore the role these acute insults have on endothelial function and whether any lasting dysfunction exists predisposing to CVD risk.
Cardiovascular risk differs between the sexes. Women have a lower risk for developing CVD than age-matched men until the menopause, where thereafter they develop an accelerated phenotype resulting in a rapid rise in the prevalence and mortality related to CVD. This effect is thought to be mediated, in part, through oestrogens effects on endothelial function.
We aim to explore the impact of sex steroids and gender on endothelial function and how this interacts with acute and possible lasting dysfunction.
Supervisors:
Dr Richard McFarlane: Translational Medical Science for Therapy Development in Small Vessel Disease
More information on Richard's PhD project is coming soon.
Supervisors:
- Professor Colin Berry
Publications
Main, A., Mary, S. , Sin, Y. Y. , Wright, T. A., Ling, J., Blair, C. M., Smith, G. L. , Fuller, W. and Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)
Docherty, K. F. et al. (2024) Wearable accelerometer-derived measures of physical activity in heart failure: insights from the DETERMINE trials. Journal of Cardiac Failure, (Accepted for Publication)
Lee, M. et al. (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26(10), pp. 2293-2295. (doi: 10.1002/ejhf.3394) (PMID:39078467)
Docherty, K. F. et al. (2024) Effect of dapagliflozin on accelerometer-based measures of physical activity in patients with heart failure: an analysis of the DETERMINE trials. Circulation: Heart Failure, 17(10), e012349. (doi: 10.1161/CIRCHEARTFAILURE.124.012349) (PMID:39212948) (PMCID:PMC11472896)
Zhou, M., Mary, S. , Delles, C. , Padmanabhan, S. , Graham, D. , McBride, M. W. and Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0) (PMID:39259220) (Early Online Publication)
Morrow, A. et al. (2024) Zibotentan in microvascular angina: a randomized, placebo-controlled, crossover trial. Circulation, (doi: 10.1161/CIRCULATIONAHA.124.069901) (PMID:39217504) (Early Online Publication)
Butt, J. et al. (2024) Dapagliflozin and timing of prior heart failure hospitalization a patient-level meta-analysis of DAPA-HF and DELIVER. JACC: Heart Failure, 12(9), pp. 1586-1599. (doi: 10.1016/j.jchf.2024.01.018) (PMID:38573262)
Abdin, A. et al. (2024) Effects of dapagliflozin according to QRS duration across the spectrum of left ventricular ejection fraction: an analysis of DAPA-HF and DELIVER. European Journal of Heart Failure, 26(9), pp. 1952-1963. (doi: 10.1002/ejhf.3350) (PMID:39016033)
Butt, J. H. et al. (2024) Therapeutic effects of heart failure medical therapies on standardized kidney outcomes: Comprehensive individual participant-level analysis of 6 randomized clinical trials. Circulation, (doi: 10.1161/circulationaha.124.071110) (PMID:39217458) (Accepted for Publication)
Yang, M. et al. (2024) Clinical characteristics and outcomes of patients aged 80 years and over with heart failure: Need for better treatment. European Journal of Heart Failure, (doi: 10.1002/ejhf.3417) (PMID:39169481) (Early Online Publication)
Graham, F. J., Guha, K., Cleland, J. G. and Kalra, P. R. (2024) Treating iron deficiency in patients with heart failure: what, why, when, how, where and who. Heart, (doi: 10.1136/heartjnl-2022-322030) (PMID:39160066) (Early Online Publication)
Elyan, B. M.P. , Sullivan, M. K. , Hedley, J., De La Mata, N., Webster, A. C., Venugopal, B., Jones, R. J. , Lang, N. N. , Mark, P. B. and Lees, J. S. (2024) The impact of VEGF signalling pathway inhibitors and/or immune checkpoint inhibitors on kidney function over time: a single centre retrospective analysis. BJC Reports, 2, 57. (doi: 10.1038/s44276-024-00081-7)
Petermann-Rocha, F., Zhou, Z. , Mathers, J. C., Celis-Morales, C. , Raubenheimer, D., Sattar, N. , Pell, J. P., Forrest, E. and Ho, F. K. (2024) Diet modifies the association between alcohol consumption and severe alcohol-related liver disease incidence. Nature Communications, 15(1), 6880. (doi: 10.1038/s41467-024-51314-9) (PMID:39128919) (PMCID:PMC11317484)
Richardson, S. H., Mackenzie, J., Thekkethil, N., Feng, L., Lee, J., Berry, C. , Hill, N. , Luo, X. and Gao, H. (2024) Cardiac perfusion coupled with a structured coronary network tree. Computer Methods in Applied Mechanics and Engineering, 428, 117083. (doi: 10.1016/j.cma.2024.117083)
Carberry, J. et al. (2024) Empagliflozin to prevent progressive adverse remodelling after myocardial infarction (EMPRESS-MI): rationale and design. ESC Heart Failure, 11(4), pp. 2001-2012. (doi: 10.1002/ehf2.14830) (PMID:38715187) (PMCID:PMC11287338)
Yang, M. et al. (2024) Geographical variation in patient characteristics and outcomes in heart failure with mildly reduced and preserved ejection fraction. European Journal of Heart Failure, 26(8), pp. 1788-1803. (doi: 10.1002/ejhf.3352) (PMID:38923118)
McCallum, L. et al. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.124.23122) (PMID:39077768) (Early Online Publication)
Delles, C. , Setjiadi, D. and Geddes, C. (2024) Blood pressure measurement technique in clinical practice. Research Square, (doi: 10.21203/rs.3.rs-4635130/v1)
Shead, K. D., Huethorst, E. , Burton, F., Lang, N. , Myles, R. C. and Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology, (Accepted for Publication)
Ezad, S. M. et al. (2024) Impact of Anatomical and Viability-Guided Completeness of Revascularization on Clinical Outcomes in Ischemic Cardiomyopathy. Journal of the American College of Cardiology, 84(4), pp. 340-350. (doi: 10.1016/j.jacc.2024.04.043) (PMID:38759904) (PMCID:PMC11250908)
Yang, M. et al. (2024) Dapagliflozin and quality of life measured using the EuroQol 5-Dimension questionnaire in patients with HFrEF and HFmrEF/HFpEF. European Journal of Heart Failure, 26(7), pp. 1524-1538. (doi: 10.1002/ejhf.3263) (PMID:38700986)
Conrad, N. et al. (2024) Temporal trends and patterns in cardiovascular disease incidence: a population-based study in 22 million individuals. British Medical Journal, 385, e078523. (doi: 10.1136/bmj-2023-078523) (PMID:38925788) (PMCID:PMC11203392)
Shen, L. et al. (2024) Revisiting race and the benefit of RAS blockade in heart failure. A meta-analysis of randomized clinical trials. JAMA: Journal of the American Medical Association, 331(24), 2094. (doi: 10.1001/jama.2024.6774) (PMID:38809561)
Matsumoto, S. et al. (2024) Mineralocorticoid receptor antagonists in patients with heart failure and impaired renal function. Journal of the American College of Cardiology, 83(24), pp. 2426-2436. (doi: 10.1016/j.jacc.2024.03.426) (PMID:38739064)
Friday, J. M. et al. (2024) Loop diuretic utilisation with or without heart failure: impact on prognosis. European Heart Journal, (doi: 10.1093/eurheartj/ehae345) (PMID:38845446) (Early Online Publication)
Rankin, S. et al. (2024) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients using 18F-FDG positron emission tomography. bioRxiv, (doi: 10.1101/2024.05.30.596741)
Tran, T. Q. B. et al. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, 6(6), pp. 798-804. (doi: 10.1016/j.cjco.2024.03.005) (PMID:39022171) (PMCID:PMC11250845)
Ang, D. T.Y., Carrick, D., Kamdar, A. , Sykes, R. , McGeoch, R. J., Collison, D., McConnachie, A. and Berry, C. (2024) Intracoronary adenosine–derived coronary flow reserve and index of microvascular resistance. Circulation: Cardiovascular Interventions, 17(6), e013667. (doi: 10.1161/circinterventions.123.013667) (PMID:38716671) (PMCID:PMC11177601)
Gök, C. and Fuller, W. (2024) Rise of palmitoylation: a new trick to tune NCX1 activity. Biochimica et Biophysica Acta: Molecular Cell Research, 1871(5), 119719. (doi: 10.1016/j.bbamcr.2024.119719) (PMID:38574822)
Padmanabhan, S. , Delles, C. and Dominiczak, A. F. (2024) Beyond genome-wide scans: advancing hypertension genomics into the future. Hypertension, 81(6), pp. 1186-1189. (doi: 10.1161/HYPERTENSIONAHA.124.21371) (PMID:38748763)
Curtain, J. P. et al. (2024) Measuring congestion with a non-invasive monitoring device in heart failure and haemodialysis: CONGEST-HF. European Journal of Heart Failure, 26(6), pp. 1383-1392. (doi: 10.1002/ejhf.3290) (PMID:38741283)
Abraham, A. et al. (2024) Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: toward precision medicine. Diabetes, 73(6), pp. 1012-1025. (doi: 10.2337/db23-1005) (PMID:38530928) (PMCID:PMC11109787)
Kondo, T. et al. (2024) Dapagliflozin and days of full health lost through death, hospitalization, and impaired well-being in DAPA-HF. Journal of the American College of Cardiology, 83(20), pp. 1973-1986. (doi: 10.1016/j.jacc.2024.03.385) (PMID:38537918)
Kondo, T. et al. (2024) A hierarchical kidney outcome using win statistics in patients with heart failure from the DAPA-HF and DELIVER trials. Nature Medicine, 30(5), pp. 1432-1439. (doi: 10.1038/s41591-024-02941-8) (PMID:38710952) (PMCID:PMC11108780)
Butler, J. et al. (2024) Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials. Lancet, 403(10437), pp. 1635-1648. (doi: 10.1016/S0140-6736(24)00469-0) (PMID:38599221)
Rankin, S., Elyan, B. , Jones, R. , Venugopal, B., Mark, P. B. , Lees, J. S. , Petrie, M. C. and Lang, N. N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6(2), pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010) (PMID:38774021) (PMCID:PMC11103039)
Glen, C. et al. (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110(9), pp. 650-656. (doi: 10.1136/heartjnl-2023-323437) (PMID:38103912) (PMCID:PMC11041571)
Sattar, N. , Presslie, C., Rutter, M. K. and McGuire,, D. K. (2024) Cardiovascular and kidney risks in individuals with type 2 diabetes: contemporary understanding with greater emphasis on excess adiposity. Diabetes Care, 47(4), pp. 531-543. (doi: 10.2337/dci23-0041) (PMID:38412040)
Sani, R. N., Connelly, P. J. , Toft, M., Rowa-Dewar, N., Delles, C. , Gasevic, D. and Karaye, K. M. (2024) Rural-urban difference in the prevalence of hypertension in West Africa: a systematic review and meta-analysis. Journal of Human Hypertension, 38, pp. 352-364. (doi: 10.1038/s41371-022-00688-8) (PMID:35430612) (PMCID:PMC11001577)
Cuthbert, J. J. et al. (2024) Medicines optimization prior to discharge in patients admitted to hospital with heart failure. ESC Heart Failure, 11(2), pp. 950-961. (doi: 10.1002/ehf2.14638) (PMID:38229241) (PMCID:PMC10966249)
Yang, Y., Husmeier, D. , Gao, H. , Berry, C. , Carrick, D. and Radjenovic, A. (2024) Automatic detection of myocardial ischaemia using generalisable spatio-temporal hierarchical Bayesian modelling of DCE-MRI. Computerized Medical Imaging and Graphics, 113, 102333. (doi: 10.1016/j.compmedimag.2024.102333) (PMID:38281420)
Lim, M. W. S., Lucas-Herald, A. K. , Mason, A., Delles, C. and Connelly, P. J. (2024) Sex differences in the cardiovascular effects of GnRH analogues. Journal of Endocrinology, 261(1), e230309. (doi: 10.1530/JOE-23-0309) (PMID:38265843)
Rossitto, G., Bertoldi, G., Rutkowski, J. M., Mitchell, B. M. and Delles, C. (2024) Sodium, interstitium, lymphatics, and hypertension - A tale of hydraulics. Hypertension, 81(4), pp. 727-737. (doi: 10.1161/HYPERTENSIONAHA.123.17942) (PMID:38385255)
Jackson, A. M. et al. (2024) A novel score to predict left ventricular recovery in peripartum cardiomyopathy derived from the ESC EORP Peripartum Cardiomyopathy Registry. European Heart Journal, 45(16), pp. 1430-1439. (doi: 10.1093/eurheartj/ehad888) (PMID:38282532) (PMCID:PMC11032708)
Sattar, N. et al. (2024) Body mass index and cardiorenal outcomes in the EMPEROR-Preserved trial: principal findings and meta-analysis with the DELIVER trial. European Journal of Heart Failure, 26(4), pp. 900-909. (doi: 10.1002/ejhf.3221) (PMID:38558521)
Cleland, J. G.F. , Pellicori, P. and Lakhal-Littleton, S. (2024) Low serum ferritin might predict incident heart failure but why and is it clinically useful? JACC: Heart Failure, 12(3), pp. 549-551. (doi: 10.1016/j.jchf.2023.12.012) (PMID:38340135)
McCallum, L., Lip, S. , Rostron, M., Hanna, R., Salimin, N. B. P. M., Nichol, S. and Padmanabhan, S. (2024) OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring. Open Heart, 11(1), e002535. (doi: 10.1136/openhrt-2023-002535) (PMID:38429056)
Butt, J. H. et al. (2024) Heart failure, investigator-reported sleep apnea and dapagliflozin: A patient-level pooled meta-analysis of DAPA-HF and DELIVER. Journal of Cardiac Failure, 30(3), pp. 436-448. (doi: 10.1016/j.cardfail.2023.08.027) (PMID:38104937)
Sykes, R. , Hanna, R. and Berry, C. (2024) Prognostic importance of fractional flow reserve and left ventricular systolic dysfunction after percutaneous coronary intervention. JACC: Asia, 4(3), pp. 241-243. (doi: 10.1016/j.jacasi.2023.12.002) (PMID:38463675) (PMCID:PMC10920047)
Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, 32. (doi: 10.1038/s43856-024-00455-5) (PMID:38418616) (PMCID:PMC10901805)
Bosserdt, M. et al. (2024) Age and computed tomography and invasive coronary angiography in stable chest pain: a prespecified secondary analysis of the discharge randomized clinical trial. JAMA Cardiology, 9(4), pp. 346-356. (doi: 10.1001/jamacardio.2024.0001) (PMID:38416472)
UK HFpEF Collaborative Group, and , (2024) Rationale and design of the United Kingdom Heart Failure with Preserved Ejection Fraction Registry. Heart, 110(5), pp. 359-365. (doi: 10.1136/heartjnl-2023-323049) (PMID:37827557)
Hoare, D., Kingsmore, D., Holsgrove, M., Russell, E., Kirimi, M. T., Czyzewski, J., Mirzai, N., Kennedy, S. , Neale, S. L. and Mercer, J. R. (2024) Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft. Communications Medicine, 4, 15. (doi: 10.1038/s43856-024-00436-8) (PMID:38316912) (PMCID:PMC10844314)
Sykes, R. et al. (2024) Effect of body mass index on effectiveness of CT versus invasive coronary angiography in stable chest pain: The DISCHARGE trial. Radiology, 310(2), e230591. (doi: 10.1148/radiol.230591) (PMID:38349247)
Cleland, J. G.F. et al. (2024) Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial. ESC Heart Failure, 11(1), pp. 209-218. (doi: 10.1002/ehf2.14465) (PMID:37939716) (PMCID:PMC10804163)
Brum, W. S., Docherty, K. F. , Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V. and Blennow, K. (2024) Effect of neprilysin inhibition on Alzheimer disease plasma biomarkers: a secondary analysis of a randomized clinical trial. JAMA Neurology, 81(2), pp. 197-200. (doi: 10.1001/jamaneurol.2023.4719) (PMID:38109077) (PMCID:PMC10728797)
Butt, J. H. et al. (2024) Heart failure with preserved ejection fraction, red cell distribution width, and sacubitril/valsartan. ESC Heart Failure, 11(1), pp. 65-77. (doi: 10.1002/ehf2.14558) (PMID:37813587) (PMCID:PMC10804200)
Vardeny, O. et al. (2024) Dapagliflozin and mode of death in heart failure with improved ejection fraction: A post hoc analysis of the DELIVER trial. JAMA Cardiology, 9(3), pp. 283-289. (doi: 10.1001/jamacardio.2023.5318) (PMID:38265835) (PMCID:PMC10809142)
Petrie, M. C. et al. (2024) Pulmonary congestion and left ventricular dysfunction after myocardial infarction: insights from the PARADISE-MI trial. Circulation, 149(4), pp. 335-38. (doi: 10.1161/CIRCULATIONAHA.123.066163) (PMID:38252738)
Mary, S. et al. (2024) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension. Journal of Nephrology, (doi: 10.1007/s40620-023-01830-6) (PMID:38236469) (Early Online Publication)
Kosiborod, M. N. et al. (2024) Effects of semaglutide on symptoms, function, and quality of life in patients with heart failure with preserved ejection fraction and obesity: a prespecified analysis of the STEP-HFpEF trial. Circulation, 149(3), pp. 204-216. (doi: 10.1161/circulationaha.123.067505) (PMID:37952180) (PMCID:PMC10782938)
Sidik, N. P. et al. (2024) Invasive endotyping in patients with angina and no obstructive coronary artery disease: a randomized controlled trial. Circulation, 149(1), pp. 7-23. (doi: 10.1161/CIRCULATIONAHA.123.064751) (PMID:37795617)
Osmanska, J. et al. (2024) A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studies. European Heart Journal: Cardiovascular Pharmacotherapy, 10, pp. 35-44. (doi: 10.1093/ehjcvp/pvad073) (PMID:37804170) (PMCID:PMC10766906)
Cleland, J. G. F. (2024) Defining iron deficiency in patients with heart failure. Nature Reviews Cardiology, 21(1), pp. 1-2. (doi: 10.1038/s41569-023-00951-6) (PMID:37875635)
Jackson, A. et al. (2024) Outcomes at one year in women with peripartum cardiomyopathy: findings from the ESC EORP PPCM Registry. European Journal of Heart Failure, 26(1), pp. 34-42. (doi: 10.1002/ejhf.3055) (PMID:37823238)
McDowell, K., Adamson, C., Jackson, C., Campbell, R., Welsh, P. , Petrie, M. C. , McMurray, J. J.V. , Jhund, P. and Herring, N. (2024) Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes. European Journal of Heart Failure, 26(1), pp. 107-116. (doi: 10.1002/ejhf.3085) (PMID:37937329)
Lee, M. M.Y. , Kondo, T., Campbell, R. T., Petrie, M. C. , Sattar, N. , Solomon, S. D., Vaduganathan, M., Jhund, P. S. and McMurray, J. J.V. (2024) Effects of Renin-Angiotensin system blockers on outcomes from COVID-19: a systematic review and meta-analysis of randomised controlled trials. European Heart Journal: Cardiovascular Pharmacotherapy, 10(1), pp. 68-80. (doi: 10.1093/ehjcvp/pvad067) (PMID:37740450) (PMCID:PMC10766905)
Corbin, L. J. et al. (2024) The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 67(1), pp. 74-87. (doi: 10.1007/s00125-023-06019-x) (PMID:37878066) (PMCID:PMC10709482)
Lee, M. M.Y. , Lean, M. E.J. , Sattar, N. and Petrie, M. C. (2023) Appetite and its regulation: Are there palatable interventions for heart failure? Current Heart Failure Reports, 21, pp. 1-4. (doi: 10.1007/s11897-023-00637-7) (PMID:38133864) (PMCID:PMC10827951)
Glen, C., Adam, S., Coats, C. J. and Lang, N. N. (2023) Reply: Cardiotoxicity of BRAF/MEK inhibitors according to HFA/ICOS cardiotoxicity risk category. JACC: CardioOncology, 5(6), p. 850. (doi: 10.1016/j.jaccao.2023.10.003) (PMID:38204997) (PMCID:PMC10774785)
Bagordo, D., Rossi, G. P., Delles, C. , Wiig, H. and Rossitto, G. (2023) The tangram of sodium and fluid balance: salt series. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.123.19569) (Early Online Publication)
McErlane, J., McCall, P. , Willder, J., Berry, C. and Shelley, B. (2023) Cardiac biomarkers and right ventricular dysfunction are independently associated with one year mortality in patients with COVID-19 receiving mechanical ventilation: a prospective cohort study. CHEST Critical Care, 1(3), 100015. (doi: 10.1016/j.chstcc.2023.100015)
Kondo, T. et al. (2023) Efficacy of dapagliflozin according to heart rate: A patient-level pooled analysis of DAPA-HF and DELIVER. Circulation: Heart Failure, 16(12), e010898. (doi: 10.1161/CIRCHEARTFAILURE.123.010898) (PMID:37886880)
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New Opportunities
Cardiovascular Oncology
The cardiovascular-oncology theme in SCMH, initiated in 2018 and led by Prof Rhian Touyz and Dr Ninian Lang, focuses on the effects of cancer and its treatment upon cardiovascular disease. The aim is to minimise the competing risks of cardiovascular disease in patients with cancer. This theme is truly at the interface between cardiovascular medicine and cancer – at the research and clinical levels. The theme is a component of the strategic objectives of a British Heart Foundation (BHF) Centre of Excellence Award and is well supported by further specific research grants.
Please see the main SCMH research pages for more detailed information on the Cardiovascular Oncology theme.
Multi-morbidity and Chronic Diseases
COMING SOON