8 TEM images showing LNPs increasing in size as preparation conditions change
8 TEM images showing LNPs increasing in size as preparation conditions change

Tailoring lipid nanoparticle dimensions through manufacturing processes

Fri, 25 Oct 2024 17:42:00 BST

Caitlin McMillan, Amy Druschitz, Stephen Rumbelow, Ankita Borah, Burcu Binici, Zahra Rattray and Yvonne Perrie. (2024), RSC Pharmaceutics

Schematic showing changes in USP1 on binding of KSQ-4279
Schematic showing changes in USP1 on binding of KSQ-4279

Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279

Tue, 27 Aug 2024 16:18:40 BST

Martin Luke Rennie, Mehmet Gundogdu, Connor Arkinson, Steven Liness, Sheelagh Frame and Helen Walden. (2024), Journal of Medicinal Chemistry

Molecular graphics showing orthogonal views of the rhizosin polyketide synthase module
Molecular graphics showing orthogonal views of the rhizosin polyketide synthase module

Trapping of a Polyketide Synthase Module After C-C Bond Formation Reveals Transient Acyl Carrier Domain Interactions

Sun, 24 Dec 2023 15:40:00 GMT

Maria Dell, Mai An Tran, Michael J Capper, Srividhya Sundaram, Jonas Fieldler, Jesko Koehnke, Ute A Hellmich and Christian Hertweck. (2023). Angewandte Chemie International Edition

Cryo-EM map of SsoCsm with fitted structure and schematic diagram showing subunits
Cryo-EM map of SsoCsm with fitted structure and schematic diagram showing subunits

Structure of the Saccharolobus solfataricus type III-D CRISPR effector

Mon, 13 Feb 2023 18:04:00 GMT

Giuseppe Cannone, Dmytro Kompaniiets, Shirley Graham, Malcom F White and Laura Spagnolo (2023), Current Research in Structural Biology

FANCIUb‐FANCD2 (IUbD2) structure bound to double‐stranded DNA. The structure was determined by cryo‐EM, using a 4.1 Å global resolution map
FANCIUb‐FANCD2 (IUbD2) structure bound to double‐stranded DNA. The structure was determined by cryo‐EM, using a 4.1 Å global resolution map

Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination

Thu, 17 Nov 2022 13:52:24 GMT

Kimon Lemonidis, Martin L Rennie, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley and Helen Walden. (2022), The EMBO Journal

Cryo-EM map of complex solved in this study, with inset areas showing structural change of His593 on inhibitor binding
Cryo-EM map of complex solved in this study, with inset areas showing structural change of His593 on inhibitor binding

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

Thu, 29 Sep 2022 13:14:00 BST

Martin L Rennie. Connor Arkinson, Viduth K Chaugule and Helen Walden (2022). Science Advances

Electron micrograph of TIR-SAVED, and a segment of the cryo-EM reconstruction
Electron micrograph of TIR-SAVED, and a segment of the cryo-EM reconstruction

Cyclic nucleotide-induced helical structure activates a TIR immune effector

Wed, 10 Aug 2022 16:48:00 BST

Gaëlle Hogrel, Abbie Guild, Shirley Graham, Hannah Rickman, Sabine Grüschow, Quentin Bertrand, Laura Spagnolo and Malcolm F White (2022). Nature

Segemented slices through cryo-electron tomogram showing exocyst-mediated liposome tethering
Segemented slices through cryo-electron tomogram showing exocyst-mediated liposome tethering

A mechanism for exocyst-mediated tethering via Arf6 and PIP5K1C-driven phosphoinositide conversion

Mon, 11 Jul 2022 17:44:16 BST

Hannes Maib and David H Murray. (2022). Current Biology

Scheme and cryo-EM images of the aggregation of Poly(N,N-Diethylacrylamide)-b-Poly(4-Acryloylmorpholine)
Scheme and cryo-EM images of the aggregation of Poly(N,N-Diethylacrylamide)-b-Poly(4-Acryloylmorpholine)

Stimuli-Responsive Aggregation of High Molar Mass Poly(N,N-Diethylacrylamide)-b-Poly(4-Acryloylmorpholine) in Tetrahydrofuran

Mon, 15 Nov 2021 16:54:00 GMT

Alexander Plucinski, Marko Pavlovic, Mairi Clarke, David Bhella and Bernhard VKJ Schmidt (2021). Macromolecular Rapid Communications

Cryo EM reconstruction of vesivirus 2117 VLPs
Cryo EM reconstruction of vesivirus 2117 VLPs

The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the Vesivirus genus

Thu, 15 Apr 2021 11:14:00 BST

Hazel Sutherland, Michaela J Conley, Edward Emmott, James Streetley, Ian G Goodfellow, David Bhella. (2021). Journal of Virology

Molecular structure of UAF1-USP1 bound to FANCI-FANCD2
Molecular structure of UAF1-USP1 bound to FANCI-FANCD2

Structural basis of FANCD2 deubiquitination by USP1−UAF1

Thu, 01 Apr 2021 16:00:00 BST

Martin L Rennie, Connor Arkinson, Viduth K Chaugule, Rachel Toth & Helen Walden. (2021), Nature Structural and Molecular Biology

Figure from paper showing structure of ID2Ub
Figure from paper showing structure of ID2Ub

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

Wed, 10 Jun 2020 17:55:00 BST

Martin L Rennie, Kimon Lemonidis, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Laura Spagnolo & Helen Walden. (2020) EMBO Reports, e50133.