Professor Douglas Morrison
- Professor of Isotope Bioscience (Scottish Universities Environmental Research Centre)
telephone:
01355270134
email:
Douglas.Morrison@glasgow.ac.uk
Suerc, Rankine Avenue, East Kilbride G75 0QF
https://orcid.org/0000-0002-4161-5699Research interests
Design and synthesis of novel metaprobes
Metaprobes are isotopically labelled molecular probes for measuring metabolic process in vivo. They are designed to release the isotope labelled probe at the correct physiological site e.g. the colon for studies of bacterial metabolism.
Carbohydrate metabolism
Exploiting natural isotopic abundance variances (C3 vs. C4 plant carbohydrates) and stable isotope enrichment studies to determine the fate of dietary carbohydrates through digestion and fermentation and the impact of these processes on health and disease.
Gut bacteria in health and disease
Development of in vitro and in vivo stable isotope methods to probe the function and activity of bacteria within the gut in health and disease.
Compound-specific isotope analysis
Development of GC and LC based methods for online compound specific isotope analysis.
Functional metabolomics
Development of instrumental platforms for analysis of multiple, isotopically labelled metabolites and design of tracers to probe the flux through targeted metabolic pathways in biological systems.
Publications
2024
Malcomson, F. C. et al. (2024) Effects of non-digestible carbohydrates on gut microbiota and microbial metabolites: a randomised, controlled dietary intervention in healthy individuals. British Journal of Nutrition, (doi: 10.1017/S000711452400271X) (PMID:39494600) (Early Online Publication)
Kelly, P., Shivakumar, N., Morrison, D. , Hegde, S. and Kurpad, A. (2024) Is there dietary macronutrient malabsorption in children with environmental enteropathy? European Journal of Clinical Nutrition, (doi: 10.1038/s41430-024-01510-z) (PMID:39379550) (Early Online Publication)
Shivakumar, N. et al. (2024) A cross-sectional study of associations between the 13C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy. American Journal of Clinical Nutrition, (doi: 10.1016/j.ajcnut.2024.10.001) (PMID:39384142) (Early Online Publication)
Pugh, J. E. et al. (2024) Increase in colonic PRopionate as a method of prEVENTing weight gain over 12 months in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group trial. EClinicalMedicine, 76, 102844. (doi: 10.1016/j.eclinm.2024.102844) (PMID:39391015) (PMCID:PMC11466568)
Van Wyk, H., Lee, G. O., Schillinger, R. J., Edwards, C. A. , Morrison, D. and Brouwer, A. F. (2024) Performance of empirical and model-based classifiers for detecting sucrase-isomaltase inhibition using the 13C-sucrose breath test. Journal of Breath Research, 18(4), 041003. (doi: 10.1088/1752-7163/ad748d) (PMID:39197471) (PMCID:PMC11385691)
Phiri, T. N. et al. (2024) Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: a cross-sectional study protocol. F1000Research, 13, 956. (doi: 10.12688/f1000research.154471.1)
Kiosia, A. et al. (2024) The double burden of malnutrition in individuals: Identifying key challenges and re-thinking research focus. Nutrition Bulletin, 49(2), pp. 132-145. (doi: 10.1111/nbu.12670) (PMID:38576109)
Jones, D. J., Celis-Morales, C. , Gray, S. R. , Morrison, D. J. , Ozanne, S. E., Jain, M., Mattin, L. R. and Burden, S. (2024) Effect of sustainably sourced protein consumption on nutrient intake and gut health in older adults: a systematic review. Nutrients, 16(9), 1398. (doi: 10.3390/nu16091398) (PMID:38732644) (PMCID:PMC11085519)
Brouwer, A. F., Lee, G. O., Van Wyk, H., Schillinger, R. J., Edwards, C. A. and Morrison, D. J. (2024) A model-based 13C-sucrose breath test diagnostic for gut function disorders characterized by a loss of sucrase-isomaltase enzymatic activity. Journal of Nutrition, 154(3), pp. 815-825. (doi: 10.1016/j.tjnut.2023.11.017) (PMID:37995914)
2023
Brouwer, A. F., Lee, G. O., Schillinger, R. J., Edwards, C. A. , Van Wyk, H., Yazbeck, R. and Morrison, D. J. (2023) Mechanistic inference of the metabolic rates underlying 13C breath test curves. Journal of Pharmacokinetics and Pharmacodynamics, 50(3), pp. 203-214. (doi: 10.1007/s10928-023-09847-x) (PMID:36790613)
2022
O'Brien, Á. C. et al. (2022) Using organic contaminants to constrain the terrestrial journey of the martian meteorite Lafayette. Astrobiology, 22(11), pp. 1351-1362. (doi: 10.1089/ast.2021.0180) (PMID:36264546) (PMCID:PMC9618387)
Pugh, J. E. et al. (2022) Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group study to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months. F1000Research, (doi: 10.12688/f1000research.125950.1)
O'Brien, A. , Hallis, L. , Regnault, C., Morrison, D. , Blackburn, G., McKay, E. , Whitfield, P. and Lee, M. (2022) Soluble Organics Within the Newly Fallen Winchcombe Meteorite. 85th Annual Meeting of The Meteoritical Society, Glasgow, Scotland, 14-19 Aug 2022.
Schillinger, R. J. et al. (2022) 13C-sucrose breath test for the non-invasive assessment of environmental enteropathy in Zambian adults. Frontiers in Medicine, 9, 904339. (doi: 10.3389/fmed.2022.904339) (PMID:35966866) (PMCID:PMC9372340)
Rowe, J. T., King, R. F.G.J., King, A. J., Morrison, D. J. , Preston, T. , Wilson, O. J. and O'Hara, J. P. (2022) Glucose and fructose hydrogel enhances running performance, exogenous carbohydrate oxidation, and gastrointestinal tolerance. Medicine and Science in Sports and Exercise, 54(1), pp. 129-140. (doi: 10.1249/MSS.0000000000002764) (PMID:34334720)
2021
Harris, H. C., Morrison, D. J. and Edwards, C. A. (2021) Impact of the source of fermentable carbohydrate on SCFA production by human gut microbiota in vitro: a systematic scoping review and secondary analysis. Critical Reviews in Food Science and Nutrition, 61(22), pp. 3892-3903. (doi: 10.1080/10408398.2020.1809991) (PMID:32865002)
Thompson, A. J., Bourke, C. D., Robertson, R. C., Shivakumar, N., Edwards, C. , Preston, T. , Holmes, E., Kelly, P., Frost, G. and Morrison, D. J. (2021) Understanding the role of the gut in undernutrition: what can technology tell us? Gut, 70, pp. 1580-1594. (doi: 10.1136/gutjnl-2020-323609) (PMID:34103403)
Calder, N. et al. (2021) Modifying Gut Integrity and Microbiome in children with severe acute malnutrition using LEgume-Based Feeds [MIMBLE]: A pilot trial. Cell Reports Medicine, 2(5), 100280. (doi: 10.1016/j.xcrm.2021.100280)
Griffiths, A., Deighton, K., Boos, C. J., Rowe, J., Morrison, D. , Preston, T. , King, R. and O’Hara, J. P. (2021) Carbohydrate supplementation and the influence of breakfast on fuel use in hypoxia. Medicine and Science in Sports and Exercise, 53(4), pp. 785-795. (doi: 10.1249/MSS.0000000000002536) (PMID:33044437)
2020
Lee, G. O. et al. (2020) Optimization, validation and field-applicability of a 13C-sucrose breath test to assess intestinal function in environmental enteropathy among children in resource poor settings: study protocol for a prospective study in Bangladesh, India, Kenya, Jamaica, Peru, and Zambia. BMJ Open, 10, e035841. (doi: 10.1136/bmjopen-2019-035841) (PMID:33203623)
Petropoulou, K. et al. (2020) A natural mutation in Pisum sativum L. (pea) alters starch assembly and improves glucose homeostasis in humans. Nature Food, 1(11), pp. 693-704. (doi: 10.1038/s43016-020-00159-8)
Yuille, S., MacKay, W.G., Morrison, D.J. and Tedford, M.C. (2020) Drivers of Clostridioides difficile hypervirulent ribotype 027 spore germination, vegetative cell growth and toxin production in vitro. Clinical Microbiology and Infection, 26(7), 941.e1-941.e7. (doi: 10.1016/j.cmi.2019.11.004) (PMID:31715298)
Coelho, M. O.C., Monteyne, A. J., Dunlop, M. V., Harris, H. C., Morrison, D. J. , Stephens, F. B. and Wall, B. T. (2020) Mycoprotein as a possible alternative source of dietary protein to support muscle and metabolic health. Nutrition Reviews, 78(6), pp. 486-497. (doi: 10.1093/nutrit/nuz077) (PMID:31841152)
Havlik, J. , Marinello, V., Gardyne, A., Hou, M., Mullen, W. , Morrison, D. J. , Preston, T. , Combet, E. and Edwards, C. A. (2020) Dietary fibres differentially impact on the production of phenolic acids from rutin in an in vitro fermentation model of the human gut microbiota. Nutrients, 12(6), 1577. (doi: 10.3390/nu12061577) (PMID:32481553) (PMCID:PMC7352394)
Malkova, D. , Polyviou, T., Rizou, E., Gerasimidis, K. , Chambers, E. S., Preston, T. , Tedford, C. M., Frost, G. and Morrison, D. J. (2020) Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women. Metabolism, 104, 154043. (doi: 10.1016/j.metabol.2019.154043) (PMID:31790692)
Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)
2019
O'Hara, J. P. et al. (2019) Fuel use during exercise at altitude in women with glucose–fructose ingestion. Medicine and Science in Sports and Exercise, 51(12), pp. 2586-2594. (doi: 10.1249/MSS.0000000000002072) (PMID:31206498)
Chambers, E. S. et al. (2019) Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut, 68(8), pp. 1430-1438. (doi: 10.1136/gutjnl-2019-318424) (PMID:30971437) (PMCID:PMC6691855)
King, A. J., O'Hara, J. P., Arjomandkhah, N. C., Rowe, J., Morrison, D. , Preston, T. and King, R. F.G.J. (2019) Liver and muscle glycogen oxidation and performance with dose variation of glucose-fructose ingestion during prolonged (3-h) exercise. European Journal of Applied Physiology, 119(5), pp. 1157-1169. (doi: 10.1007/s00421-019-04106-9) (PMID:30840136)
Byrne, C. S., Chambers, E. S., Preston, T. , Tedford, C., Brignardello-Guerra, J., Garcia-Perez, I., Holmes, E., Wallis, G. A., Morrison, D. J. and Frost, G. S. (2019) Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure: a randomised crossover study. Nutrients, 11(4), 861. (doi: 10.3390/nu11040861) (PMID:30995824) (PMCID:PMC6520886)
Harris, H. C., Edwards, C. A. and Morrison, D. J. (2019) Short chain fatty acid production from mycoprotein and mycoprotein fibre in an in vitro fermentation model. Nutrients, 11(4), 800. (doi: 10.3390/nu11040800)
Chambers, E. S. et al. (2019) The effects of dietary supplementation with inulin and inulin‐propionate ester on hepatic steatosis in adults with non‐alcoholic fatty liver disease. Diabetes, Obesity and Metabolism, 21(2), pp. 372-376. (doi: 10.1111/dom.13500) (PMID:30098126)
2018
Chambers, E. S., Preston, T. , Frost, G. and Morrison, D. J. (2018) Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health. Current Nutrition Reports, 7(4), pp. 198-206. (doi: 10.1007/s13668-018-0248-8) (PMID:30264354) (PMCID:PMC6244749)
Drew, J. E. et al. (2018) Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal taxonomic composition. Scientific Reports, 8, 15566. (doi: 10.1038/s41598-018-34081-8) (PMID:30349136) (PMCID:PMC6197265)
Byrne, C. S., Preston, T. , Brignardello, J., Garcia-Perez, I., Holmes, E., Frost, G. and Morrison, D. J. (2018) The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined 13CO2/H2 breath tests. Journal of Breath Research, 12(4), 046006. (doi: 10.1088/1752-7163/aad3f1) (PMID:30015629)
Chambers, E. S., Byrne, C. S., Aspey, K., Chen, Y., Khan, S., Morrison, D. J. and Frost, G. (2018) Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans. Diabetes, Obesity and Metabolism, 20(4), pp. 1034-1039. (doi: 10.1111/dom.13159) (PMID:29134744) (PMCID:PMC5873405)
King, A. J., O'Hara, J. P., Morrison, D. J. , Preston, T. and King, R. F.G.J. (2018) Carbohydrate dose influences liver and muscle glycogenoxidation and performance during prolonged exercise. Physiological Reports, 6(1), e13555. (doi: 10.14814/phy2.13555) (PMID:29333721) (PMCID:PMC5789655)
Reichardt, N. et al. (2018) Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production. ISME Journal, 12, pp. 610-622. (doi: 10.1038/ismej.2017.196) (PMID:29192904)
2017
Edwards, C.A. , Havlik, J. , Cong, W. , Mullen, W. , Preston, T. , Morrison, D.J. and Combet, E. (2017) Polyphenols and health: Interactions between fibre, plant polyphenols and the gut microbiota. Nutrition Bulletin, 42(4), pp. 356-360. (doi: 10.1111/nbu.12296) (PMID:29200959) (PMCID:PMC5698720)
Pingitore, A. et al. (2017) The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro. Diabetes, Obesity and Metabolism, 19(2), pp. 257-265. (doi: 10.1111/dom.12811) (PMID:27761989)
Butler, R. N., Kosek, M., Krebs, N. F., Loechl, C., Loy, A., Owino, V., Zimmermann, M. B. and Morrison, D. J. (2017) Stable isotope techniques for the assessment of host and microbiota response during gastrointestinal dysfunction. Journal of Pediatric Gastroenterology and Nutrition, 64(1), pp. 8-14. (doi: 10.1097/MPG.0000000000001373) (PMID:27632432)
Morrison, D. J. , Harris, H. C. and Edwards, C. A. (2017) Impact of glycosidic bond configuration on short chain fatty acid production from model fermentable carbohydrates by the human gut microbiota. Nutrients, 9(1), 26. (doi: 10.3390/nu9010026) (PMID:28045429)
O'Hara, J. P. et al. (2017) A comparison of substrate oxidation during prolonged exercise in men at terrestrial altitude and normobaric normoxia following the coingestion of 13C glucose and 13C fructose. Physiological Reports, 5(1), e13101. (doi: 10.14814/phy2.13101) (PMID:28082428) (PMCID:PMC5256160)
2016
Petropoulou, K. et al. (2016) Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis. Nutrition Bulletin, 41(4), pp. 372-377. (doi: 10.1111/nbu.12240)
Polyviou, T. et al. (2016) Randomised clinical study: inulin short chain fatty acid esters for targeted delivery of short chain fatty acids to the human colon. Alimentary Pharmacology and Therapeutics, 44(7), pp. 662-672. (doi: 10.1111/apt.13749) (PMID:27464984)
Byrne, C. S. et al. (2016) Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods. American Journal of Clinical Nutrition, 104(1), pp. 5-14. (doi: 10.3945/ajcn.115.126706) (PMID:27169834) (PMCID:PMC4919527)
Morrison, D. J. and Preston, T. (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes, 7(3), pp. 189-200. (doi: 10.1080/19490976.2015.1134082) (PMID:26963409)
2015
Chambers, E. S. et al. (2015) Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut, 64(11), pp. 1744-1754. (doi: 10.1136/gutjnl-2014-307913) (PMID:25500202) (PMCID:PMC4680171)
Yuille, S., Mackay, W. G., Morrison, D. J. and Tedford, M. C. (2015) Optimising gut colonisation resistance against Clostridium difficile infection. European Journal of Clinical Microbiology and Infectious Diseases, 34(11), pp. 2161-2166. (doi: 10.1007/s10096-015-2479-6) (PMID:26354525)
Byrne, C. S., Chambers, E. S., Morrison, D. J. and Frost, G. (2015) The role of short chain fatty acids in appetite regulation and energy homeostasis. International Journal of Obesity, 39(9), pp. 1331-1338. (doi: 10.1038/ijo.2015.84) (PMID:25971927) (PMCID:PMC4564526)
Chambers, E. S., Morrison, D.J. , Tedford, M.C. and Frost, G. (2015) A novel dietary strategy to increase colonic propionate production in humans and improve appetite regulation and bodyweight management. Nutrition Bulletin, 40(3), pp. 227-230. (doi: 10.1111/nbu.12157)
Chambers, E. S., Morrison, D. J. and Frost, G. (2015) Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms? Proceedings of the Nutrition Society, 74(3), pp. 328-336. (doi: 10.1017/S0029665114001657) (PMID:25497601)
Harris, H.C., Edwards, C.A. and Morrison, D.J. (2015) Molecular determinants of short chain fatty acid production: influence of glycosidic bond configuration. Proceedings of the Nutrition Society, 74(OCE1), E71. (doi: 10.1017/S0029665115000865)
2014
Imperial Innovations Limited and University of Glasgow (2014) Compounds and Their Effects on Appetite Control and Insulin Sensitivity. .
Harris, H., Edwards, C.A. and Morrison, D.J. (2014) Standardisation of units for short chain fatty acid production from in vitro fermentation systems. Proceedings of the Nutrition Society, 73(OCE1), E3. (doi: 10.1017/S0029665114000172)
Frost, G. et al. (2014) The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nature Communications, 5, (doi: 10.1038/ncomms4611)
2013
Czank, C., Cassidy, A., Zhang, Q., Morrison, D.J. , Preston, T. , Kroon, P.A., Botting, N.P. and Kay, C.D. (2013) Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study. American Journal of Clinical Nutrition, 97(5), pp. 995-1003. (doi: 10.3945/ajcn.112.049247)
O'Hara, J.P., Carroll, S., Cooke, C.B., Morrison, D.J. , Preston, T. and King, R.F.G.J. (2013) Pre-exercise galactose and glucose ingestion on fuel utilization during exercise. Medicine and Science in Sports and Exercise, 44(10), pp. 1958-1967. (doi: 10.1249/MSS.0b013e318258bf85)
2012
Lee, Y.Y., Whiting, J.G.H., Robertson, E.V., Derakshan, M.H., Wirz, A.A., Smith, D., Morrison, D.J. , Kelman, A.W. and McColl, K.E.L. (2012) Kinetics of transient hiatus hernia during transient lower esophageal sphincter relaxations and swallows in healthy subjects. Neurogastroenterology and Motility, 24(11), pp. 990-998. (doi: 10.1111/j.1365-2982.2012.01948.x)
2011
Morrison, D.J. , O'Hara, J.P., King, R.D.G. and Preston, T. (2011) Quantitation of plasma 13C-galactose and 13C-glucose during exercise by liquid chromatography/isotope ratiomass spectrometry. Rapid Communications in Mass Spectrometry, 25(17), pp. 2484-2488. (doi: 10.1002/rcm.5139)
Abaye, D., Morrison, D. and Preston, T. (2011) Strong anion exchange liquid chromatographic separation of protein amino acids for natural 13C-abundance determination by isotope ratio mass spectrometry. Rapid Communications in Mass Spectrometry, 25(3), pp. 429-435. (doi: 10.1002/rcm.4844)
Reichardt, N., Barclay, A.R., Weaver, L.T. and Morrison, D.J. (2011) Use of stable isotopes to measure the metabolic activity of the human intestinal microbiota. Applied and Environmental Microbiology, 77(22), pp. 8009-8014. (doi: 10.1128/AEM.05573-11)
2010
Morrison, D.J., Cooper, K. and Preston, T. (2010) Reconstructing bulk isotope ratios from compound-specific isotope ratios. Rapid Communications in Mass Spectrometry, 24(12), pp. 1799-1804. (doi: 10.1002/rcm.4577)
Morrison, D.J., Taylor, K. and Preston, T. (2010) Strong anion-exchange liquid chromatography coupled with isotope ratio mass spectrometry using a Liquiface interface. Rapid Communications in Mass Spectrometry, 24(12), pp. 1755-1762. (doi: 10.1002/rcm.4572)
2009
Derakhshan, M.H., Liptrot, S., Paul, J. , Brown, I.L., Morrison, D.J. and McColl, K.E.L. (2009) Oesophageal and gastric intestinal-type adenocarcinomas show same male predominance - due to 17 year delayed development in females. Gut, 58(1), pp. 16-23. (doi: 10.1136/gut.2008.161331)
2008
Pond, D.W., Fallick, A.E., Stevens, C.J., Morrison, D.J. and Dixon, D.R. (2008) Vertebrate nutrition in a deep-sea hydrothermal vent ecosystem: fatty acid and stable isotope evidence. Deep-Sea Research Part I: Oceanographic Research Papers, 55(12), pp. 1718-1726. (doi: 10.1016/j.dsr.2008.07.006)
Barclay, A.R., Morrison, D.J. and Weaver, L.T. (2008) What is the role of the metabolic activity of the gut microbiota in inflammatory bowel disease? Probing for answers with stable isotopes. Journal of Pediatric Gastroenterology and Nutrition, 46(5), pp. 486-495. (doi: 10.1097/MPG.0b013e3181615b3a)
2007
Bell, J., Preston, T. , Henderson, R., Strachan, F., Bron, J., Cooper, K. and Morrison, D.J. (2007) Discrimination of wild and cultured european sea bass (Dicentrarchus labrax) using chemical and isotopic analyses. Journal of Agricultural and Food Chemistry, 55, pp. 5934-5941. (doi: 10.1021/jf0704561)
Morrison, D. , Preston, T. , Bron, J.E., Hemderson, R.J., Cooper, K., Strachan, F. and Bell, J.G. (2007) Authenticating production origin of Gilthead Sea Bream (Sparus aurata) by chemical and isotopic fingerprinting. Lipids, 42(6), pp. 537-545. (doi: 10.1007/s11745-007-3055-3)
2006
Dodson, B., Edwards, C., Mackay, W., Morrison, D., Preston, T. and Weaver, L. (2006) Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate? British Journal of Nutrition, 96, pp. 570-577. (doi: 10.1079/BJN20061853)
2004
Morrison, D.J., Cooper, K., Waldron, S., Slater, C., Weaver, L.T. and Preston, T. (2004) A streamlined approach to the analysis of volatile fatty acids and its application to the measurement of whole-body flux. Rapid Communications in Mass Spectrometry, 18(21), pp. 2593-2600. (doi: 10.1002/rcm.1662)
2003
Dodson, B., Morrison, D. , Preston, T. and Weaver, L. (2003) Gastrointestinal handling of glycosyl [C-13]ureides. European Journal of Clinical Nutrition, 57(8), pp. 1017-1024. (doi: 10.1038/sj.ejcn.1601637)
Morrison, D.J., Dodson, B., Preston, T. and Weaver, L.T. (2003) Gastrointestinal handling of glycosyl [13C]ureides. European Journal of Clinical Nutrition, 57(8), pp. 1017-1024. (doi: 10.1038/sj.ejcn.1601637)
2002
Christian, M., Morrison, D., Dodson, B., Preston, T., Amarri, S., Franchini, F., Edwards, C. and Weaver, L. (2002) Measurement of oro-cecal transit time in young children using lactose [C-13] ureide requires further validation. Journal of Pediatric Gastroenterology and Nutrition, 34(5), pp. 570-571.
Christian, M.T., Amarri, S., Franchini, F., Preston, T., Morrison, D.J., Dodson, B., Edwards, C.A. and Weaver, L.T. (2002) Modeling C-13 breath curves to determine site and extent of starch digestion and fermentation in infants. Journal of Pediatric Gastroenterology and Nutrition, 34(2), pp. 158-164.
Edwards, C.A., Zavoshy, R., Khanna, S., Slater, C., Morrison, D.J., Preston, T. and Weaver, L.T. (2002) Production of C-13 labelled pea flour for use in human digestion and fermentation studies. Isotopes in Environmental and Health Studies, 38(3), pp. 139-147. (doi: 10.1080/10256010215130)
2001
Wyse, C.A., Preston, T., Love, S., Morrison, D.J. , Cooper, J.M. and Yam, P.S. (2001) Use of the C-13-octanoic acid breath test for assessment of solid-phase gastric emptying in dogs. American Journal of Veterinary Research, 62(12), pp. 1939-1944. (doi: 10.2460/ajvr.2001.62.1939)
Wyse, C.A., Murphy, D.M., Preston, T. , Sutton, D.G. , Morrison, D.J. , Christley, R.M. and Love, S. (2001) The 13C-octanoic acid breath test for detection of effects of meal composition on the rate of solid-phase gastric emptying in ponies. Research in Veterinary Science, 71(1), pp. 81-3. (doi: 10.1053/rvsc.2001.0488)
Wyse, C.A., Murphy, D.M., Preston, T., Sutton, D.G.M., Morrison, D.J., Christley, R.M. and Love, S. (2001) The C-13-octanoic acid breath test for detection of effects of meal composition on the rate of solid-phase gastric emptying in ponies. Research in Veterinary Science, 71(1), pp. 81-83. (doi: 10.1053/rvsc.2001.0488)
Morrison, D.J., Dodson, B., Preston, T. and Weaver, L.T. (2001) Rapid quality control analysis of C-13-enriched substrate synthesis by isotope ratio mass spectrometry. Rapid Communications in Mass Spectrometry, 15(15), pp. 1279-1282. (doi: 10.1002/rcm.341)
Wyse, C.A., Murphy, D.M., Preston, T., Morrison, D.J. and Love, S. (2001) Assessment of the rate of solid-phase gastric emptying in ponies by means of the C-13-octanoic acid breath test: a preliminary study. Equine Veterinary Journal, 33(2), pp. 197-203.
2000
Morrison, D.J. , Dodson, B., Slater, C. and Preston, T. (2000) C-13 natural abundance in the British diet: implications for C- 13 breath tests. Rapid Communications in Mass Spectrometry, 14(15), pp. 1321-1324. (doi: 10.1002/1097-0231(20000815)14:15<1321::AID-RCM946>3.0.CO;2-8)
1999
Morrison, D. , Dodson, B. and Preston, T. (1999) Measurement of urinary total 13C and 13C urea by isotope ratio mass spectrometry after administration of lactose [13C]-Ureide. Rapid Communications in Mass Spectrometry, 13(13), pp. 1252-1256. (doi: 10.1002/(SICI)1097-0231(19990715)13:13<1252::AID-RCM565>3.0.CO;2-J)
Articles
Malcomson, F. C. et al. (2024) Effects of non-digestible carbohydrates on gut microbiota and microbial metabolites: a randomised, controlled dietary intervention in healthy individuals. British Journal of Nutrition, (doi: 10.1017/S000711452400271X) (PMID:39494600) (Early Online Publication)
Kelly, P., Shivakumar, N., Morrison, D. , Hegde, S. and Kurpad, A. (2024) Is there dietary macronutrient malabsorption in children with environmental enteropathy? European Journal of Clinical Nutrition, (doi: 10.1038/s41430-024-01510-z) (PMID:39379550) (Early Online Publication)
Shivakumar, N. et al. (2024) A cross-sectional study of associations between the 13C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy. American Journal of Clinical Nutrition, (doi: 10.1016/j.ajcnut.2024.10.001) (PMID:39384142) (Early Online Publication)
Pugh, J. E. et al. (2024) Increase in colonic PRopionate as a method of prEVENTing weight gain over 12 months in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group trial. EClinicalMedicine, 76, 102844. (doi: 10.1016/j.eclinm.2024.102844) (PMID:39391015) (PMCID:PMC11466568)
Van Wyk, H., Lee, G. O., Schillinger, R. J., Edwards, C. A. , Morrison, D. and Brouwer, A. F. (2024) Performance of empirical and model-based classifiers for detecting sucrase-isomaltase inhibition using the 13C-sucrose breath test. Journal of Breath Research, 18(4), 041003. (doi: 10.1088/1752-7163/ad748d) (PMID:39197471) (PMCID:PMC11385691)
Phiri, T. N. et al. (2024) Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: a cross-sectional study protocol. F1000Research, 13, 956. (doi: 10.12688/f1000research.154471.1)
Kiosia, A. et al. (2024) The double burden of malnutrition in individuals: Identifying key challenges and re-thinking research focus. Nutrition Bulletin, 49(2), pp. 132-145. (doi: 10.1111/nbu.12670) (PMID:38576109)
Jones, D. J., Celis-Morales, C. , Gray, S. R. , Morrison, D. J. , Ozanne, S. E., Jain, M., Mattin, L. R. and Burden, S. (2024) Effect of sustainably sourced protein consumption on nutrient intake and gut health in older adults: a systematic review. Nutrients, 16(9), 1398. (doi: 10.3390/nu16091398) (PMID:38732644) (PMCID:PMC11085519)
Brouwer, A. F., Lee, G. O., Van Wyk, H., Schillinger, R. J., Edwards, C. A. and Morrison, D. J. (2024) A model-based 13C-sucrose breath test diagnostic for gut function disorders characterized by a loss of sucrase-isomaltase enzymatic activity. Journal of Nutrition, 154(3), pp. 815-825. (doi: 10.1016/j.tjnut.2023.11.017) (PMID:37995914)
Brouwer, A. F., Lee, G. O., Schillinger, R. J., Edwards, C. A. , Van Wyk, H., Yazbeck, R. and Morrison, D. J. (2023) Mechanistic inference of the metabolic rates underlying 13C breath test curves. Journal of Pharmacokinetics and Pharmacodynamics, 50(3), pp. 203-214. (doi: 10.1007/s10928-023-09847-x) (PMID:36790613)
O'Brien, Á. C. et al. (2022) Using organic contaminants to constrain the terrestrial journey of the martian meteorite Lafayette. Astrobiology, 22(11), pp. 1351-1362. (doi: 10.1089/ast.2021.0180) (PMID:36264546) (PMCID:PMC9618387)
Pugh, J. E. et al. (2022) Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group study to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months. F1000Research, (doi: 10.12688/f1000research.125950.1)
Schillinger, R. J. et al. (2022) 13C-sucrose breath test for the non-invasive assessment of environmental enteropathy in Zambian adults. Frontiers in Medicine, 9, 904339. (doi: 10.3389/fmed.2022.904339) (PMID:35966866) (PMCID:PMC9372340)
Rowe, J. T., King, R. F.G.J., King, A. J., Morrison, D. J. , Preston, T. , Wilson, O. J. and O'Hara, J. P. (2022) Glucose and fructose hydrogel enhances running performance, exogenous carbohydrate oxidation, and gastrointestinal tolerance. Medicine and Science in Sports and Exercise, 54(1), pp. 129-140. (doi: 10.1249/MSS.0000000000002764) (PMID:34334720)
Harris, H. C., Morrison, D. J. and Edwards, C. A. (2021) Impact of the source of fermentable carbohydrate on SCFA production by human gut microbiota in vitro: a systematic scoping review and secondary analysis. Critical Reviews in Food Science and Nutrition, 61(22), pp. 3892-3903. (doi: 10.1080/10408398.2020.1809991) (PMID:32865002)
Thompson, A. J., Bourke, C. D., Robertson, R. C., Shivakumar, N., Edwards, C. , Preston, T. , Holmes, E., Kelly, P., Frost, G. and Morrison, D. J. (2021) Understanding the role of the gut in undernutrition: what can technology tell us? Gut, 70, pp. 1580-1594. (doi: 10.1136/gutjnl-2020-323609) (PMID:34103403)
Calder, N. et al. (2021) Modifying Gut Integrity and Microbiome in children with severe acute malnutrition using LEgume-Based Feeds [MIMBLE]: A pilot trial. Cell Reports Medicine, 2(5), 100280. (doi: 10.1016/j.xcrm.2021.100280)
Griffiths, A., Deighton, K., Boos, C. J., Rowe, J., Morrison, D. , Preston, T. , King, R. and O’Hara, J. P. (2021) Carbohydrate supplementation and the influence of breakfast on fuel use in hypoxia. Medicine and Science in Sports and Exercise, 53(4), pp. 785-795. (doi: 10.1249/MSS.0000000000002536) (PMID:33044437)
Lee, G. O. et al. (2020) Optimization, validation and field-applicability of a 13C-sucrose breath test to assess intestinal function in environmental enteropathy among children in resource poor settings: study protocol for a prospective study in Bangladesh, India, Kenya, Jamaica, Peru, and Zambia. BMJ Open, 10, e035841. (doi: 10.1136/bmjopen-2019-035841) (PMID:33203623)
Petropoulou, K. et al. (2020) A natural mutation in Pisum sativum L. (pea) alters starch assembly and improves glucose homeostasis in humans. Nature Food, 1(11), pp. 693-704. (doi: 10.1038/s43016-020-00159-8)
Yuille, S., MacKay, W.G., Morrison, D.J. and Tedford, M.C. (2020) Drivers of Clostridioides difficile hypervirulent ribotype 027 spore germination, vegetative cell growth and toxin production in vitro. Clinical Microbiology and Infection, 26(7), 941.e1-941.e7. (doi: 10.1016/j.cmi.2019.11.004) (PMID:31715298)
Coelho, M. O.C., Monteyne, A. J., Dunlop, M. V., Harris, H. C., Morrison, D. J. , Stephens, F. B. and Wall, B. T. (2020) Mycoprotein as a possible alternative source of dietary protein to support muscle and metabolic health. Nutrition Reviews, 78(6), pp. 486-497. (doi: 10.1093/nutrit/nuz077) (PMID:31841152)
Havlik, J. , Marinello, V., Gardyne, A., Hou, M., Mullen, W. , Morrison, D. J. , Preston, T. , Combet, E. and Edwards, C. A. (2020) Dietary fibres differentially impact on the production of phenolic acids from rutin in an in vitro fermentation model of the human gut microbiota. Nutrients, 12(6), 1577. (doi: 10.3390/nu12061577) (PMID:32481553) (PMCID:PMC7352394)
Malkova, D. , Polyviou, T., Rizou, E., Gerasimidis, K. , Chambers, E. S., Preston, T. , Tedford, C. M., Frost, G. and Morrison, D. J. (2020) Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women. Metabolism, 104, 154043. (doi: 10.1016/j.metabol.2019.154043) (PMID:31790692)
Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)
O'Hara, J. P. et al. (2019) Fuel use during exercise at altitude in women with glucose–fructose ingestion. Medicine and Science in Sports and Exercise, 51(12), pp. 2586-2594. (doi: 10.1249/MSS.0000000000002072) (PMID:31206498)
Chambers, E. S. et al. (2019) Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut, 68(8), pp. 1430-1438. (doi: 10.1136/gutjnl-2019-318424) (PMID:30971437) (PMCID:PMC6691855)
King, A. J., O'Hara, J. P., Arjomandkhah, N. C., Rowe, J., Morrison, D. , Preston, T. and King, R. F.G.J. (2019) Liver and muscle glycogen oxidation and performance with dose variation of glucose-fructose ingestion during prolonged (3-h) exercise. European Journal of Applied Physiology, 119(5), pp. 1157-1169. (doi: 10.1007/s00421-019-04106-9) (PMID:30840136)
Byrne, C. S., Chambers, E. S., Preston, T. , Tedford, C., Brignardello-Guerra, J., Garcia-Perez, I., Holmes, E., Wallis, G. A., Morrison, D. J. and Frost, G. S. (2019) Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure: a randomised crossover study. Nutrients, 11(4), 861. (doi: 10.3390/nu11040861) (PMID:30995824) (PMCID:PMC6520886)
Harris, H. C., Edwards, C. A. and Morrison, D. J. (2019) Short chain fatty acid production from mycoprotein and mycoprotein fibre in an in vitro fermentation model. Nutrients, 11(4), 800. (doi: 10.3390/nu11040800)
Chambers, E. S. et al. (2019) The effects of dietary supplementation with inulin and inulin‐propionate ester on hepatic steatosis in adults with non‐alcoholic fatty liver disease. Diabetes, Obesity and Metabolism, 21(2), pp. 372-376. (doi: 10.1111/dom.13500) (PMID:30098126)
Chambers, E. S., Preston, T. , Frost, G. and Morrison, D. J. (2018) Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health. Current Nutrition Reports, 7(4), pp. 198-206. (doi: 10.1007/s13668-018-0248-8) (PMID:30264354) (PMCID:PMC6244749)
Drew, J. E. et al. (2018) Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal taxonomic composition. Scientific Reports, 8, 15566. (doi: 10.1038/s41598-018-34081-8) (PMID:30349136) (PMCID:PMC6197265)
Byrne, C. S., Preston, T. , Brignardello, J., Garcia-Perez, I., Holmes, E., Frost, G. and Morrison, D. J. (2018) The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined 13CO2/H2 breath tests. Journal of Breath Research, 12(4), 046006. (doi: 10.1088/1752-7163/aad3f1) (PMID:30015629)
Chambers, E. S., Byrne, C. S., Aspey, K., Chen, Y., Khan, S., Morrison, D. J. and Frost, G. (2018) Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans. Diabetes, Obesity and Metabolism, 20(4), pp. 1034-1039. (doi: 10.1111/dom.13159) (PMID:29134744) (PMCID:PMC5873405)
King, A. J., O'Hara, J. P., Morrison, D. J. , Preston, T. and King, R. F.G.J. (2018) Carbohydrate dose influences liver and muscle glycogenoxidation and performance during prolonged exercise. Physiological Reports, 6(1), e13555. (doi: 10.14814/phy2.13555) (PMID:29333721) (PMCID:PMC5789655)
Reichardt, N. et al. (2018) Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production. ISME Journal, 12, pp. 610-622. (doi: 10.1038/ismej.2017.196) (PMID:29192904)
Edwards, C.A. , Havlik, J. , Cong, W. , Mullen, W. , Preston, T. , Morrison, D.J. and Combet, E. (2017) Polyphenols and health: Interactions between fibre, plant polyphenols and the gut microbiota. Nutrition Bulletin, 42(4), pp. 356-360. (doi: 10.1111/nbu.12296) (PMID:29200959) (PMCID:PMC5698720)
Pingitore, A. et al. (2017) The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro. Diabetes, Obesity and Metabolism, 19(2), pp. 257-265. (doi: 10.1111/dom.12811) (PMID:27761989)
Butler, R. N., Kosek, M., Krebs, N. F., Loechl, C., Loy, A., Owino, V., Zimmermann, M. B. and Morrison, D. J. (2017) Stable isotope techniques for the assessment of host and microbiota response during gastrointestinal dysfunction. Journal of Pediatric Gastroenterology and Nutrition, 64(1), pp. 8-14. (doi: 10.1097/MPG.0000000000001373) (PMID:27632432)
Morrison, D. J. , Harris, H. C. and Edwards, C. A. (2017) Impact of glycosidic bond configuration on short chain fatty acid production from model fermentable carbohydrates by the human gut microbiota. Nutrients, 9(1), 26. (doi: 10.3390/nu9010026) (PMID:28045429)
O'Hara, J. P. et al. (2017) A comparison of substrate oxidation during prolonged exercise in men at terrestrial altitude and normobaric normoxia following the coingestion of 13C glucose and 13C fructose. Physiological Reports, 5(1), e13101. (doi: 10.14814/phy2.13101) (PMID:28082428) (PMCID:PMC5256160)
Petropoulou, K. et al. (2016) Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis. Nutrition Bulletin, 41(4), pp. 372-377. (doi: 10.1111/nbu.12240)
Polyviou, T. et al. (2016) Randomised clinical study: inulin short chain fatty acid esters for targeted delivery of short chain fatty acids to the human colon. Alimentary Pharmacology and Therapeutics, 44(7), pp. 662-672. (doi: 10.1111/apt.13749) (PMID:27464984)
Byrne, C. S. et al. (2016) Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods. American Journal of Clinical Nutrition, 104(1), pp. 5-14. (doi: 10.3945/ajcn.115.126706) (PMID:27169834) (PMCID:PMC4919527)
Morrison, D. J. and Preston, T. (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes, 7(3), pp. 189-200. (doi: 10.1080/19490976.2015.1134082) (PMID:26963409)
Chambers, E. S. et al. (2015) Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut, 64(11), pp. 1744-1754. (doi: 10.1136/gutjnl-2014-307913) (PMID:25500202) (PMCID:PMC4680171)
Yuille, S., Mackay, W. G., Morrison, D. J. and Tedford, M. C. (2015) Optimising gut colonisation resistance against Clostridium difficile infection. European Journal of Clinical Microbiology and Infectious Diseases, 34(11), pp. 2161-2166. (doi: 10.1007/s10096-015-2479-6) (PMID:26354525)
Byrne, C. S., Chambers, E. S., Morrison, D. J. and Frost, G. (2015) The role of short chain fatty acids in appetite regulation and energy homeostasis. International Journal of Obesity, 39(9), pp. 1331-1338. (doi: 10.1038/ijo.2015.84) (PMID:25971927) (PMCID:PMC4564526)
Chambers, E. S., Morrison, D.J. , Tedford, M.C. and Frost, G. (2015) A novel dietary strategy to increase colonic propionate production in humans and improve appetite regulation and bodyweight management. Nutrition Bulletin, 40(3), pp. 227-230. (doi: 10.1111/nbu.12157)
Chambers, E. S., Morrison, D. J. and Frost, G. (2015) Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms? Proceedings of the Nutrition Society, 74(3), pp. 328-336. (doi: 10.1017/S0029665114001657) (PMID:25497601)
Harris, H.C., Edwards, C.A. and Morrison, D.J. (2015) Molecular determinants of short chain fatty acid production: influence of glycosidic bond configuration. Proceedings of the Nutrition Society, 74(OCE1), E71. (doi: 10.1017/S0029665115000865)
Harris, H., Edwards, C.A. and Morrison, D.J. (2014) Standardisation of units for short chain fatty acid production from in vitro fermentation systems. Proceedings of the Nutrition Society, 73(OCE1), E3. (doi: 10.1017/S0029665114000172)
Frost, G. et al. (2014) The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nature Communications, 5, (doi: 10.1038/ncomms4611)
Czank, C., Cassidy, A., Zhang, Q., Morrison, D.J. , Preston, T. , Kroon, P.A., Botting, N.P. and Kay, C.D. (2013) Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study. American Journal of Clinical Nutrition, 97(5), pp. 995-1003. (doi: 10.3945/ajcn.112.049247)
O'Hara, J.P., Carroll, S., Cooke, C.B., Morrison, D.J. , Preston, T. and King, R.F.G.J. (2013) Pre-exercise galactose and glucose ingestion on fuel utilization during exercise. Medicine and Science in Sports and Exercise, 44(10), pp. 1958-1967. (doi: 10.1249/MSS.0b013e318258bf85)
Lee, Y.Y., Whiting, J.G.H., Robertson, E.V., Derakshan, M.H., Wirz, A.A., Smith, D., Morrison, D.J. , Kelman, A.W. and McColl, K.E.L. (2012) Kinetics of transient hiatus hernia during transient lower esophageal sphincter relaxations and swallows in healthy subjects. Neurogastroenterology and Motility, 24(11), pp. 990-998. (doi: 10.1111/j.1365-2982.2012.01948.x)
Morrison, D.J. , O'Hara, J.P., King, R.D.G. and Preston, T. (2011) Quantitation of plasma 13C-galactose and 13C-glucose during exercise by liquid chromatography/isotope ratiomass spectrometry. Rapid Communications in Mass Spectrometry, 25(17), pp. 2484-2488. (doi: 10.1002/rcm.5139)
Abaye, D., Morrison, D. and Preston, T. (2011) Strong anion exchange liquid chromatographic separation of protein amino acids for natural 13C-abundance determination by isotope ratio mass spectrometry. Rapid Communications in Mass Spectrometry, 25(3), pp. 429-435. (doi: 10.1002/rcm.4844)
Reichardt, N., Barclay, A.R., Weaver, L.T. and Morrison, D.J. (2011) Use of stable isotopes to measure the metabolic activity of the human intestinal microbiota. Applied and Environmental Microbiology, 77(22), pp. 8009-8014. (doi: 10.1128/AEM.05573-11)
Morrison, D.J., Cooper, K. and Preston, T. (2010) Reconstructing bulk isotope ratios from compound-specific isotope ratios. Rapid Communications in Mass Spectrometry, 24(12), pp. 1799-1804. (doi: 10.1002/rcm.4577)
Morrison, D.J., Taylor, K. and Preston, T. (2010) Strong anion-exchange liquid chromatography coupled with isotope ratio mass spectrometry using a Liquiface interface. Rapid Communications in Mass Spectrometry, 24(12), pp. 1755-1762. (doi: 10.1002/rcm.4572)
Derakhshan, M.H., Liptrot, S., Paul, J. , Brown, I.L., Morrison, D.J. and McColl, K.E.L. (2009) Oesophageal and gastric intestinal-type adenocarcinomas show same male predominance - due to 17 year delayed development in females. Gut, 58(1), pp. 16-23. (doi: 10.1136/gut.2008.161331)
Pond, D.W., Fallick, A.E., Stevens, C.J., Morrison, D.J. and Dixon, D.R. (2008) Vertebrate nutrition in a deep-sea hydrothermal vent ecosystem: fatty acid and stable isotope evidence. Deep-Sea Research Part I: Oceanographic Research Papers, 55(12), pp. 1718-1726. (doi: 10.1016/j.dsr.2008.07.006)
Barclay, A.R., Morrison, D.J. and Weaver, L.T. (2008) What is the role of the metabolic activity of the gut microbiota in inflammatory bowel disease? Probing for answers with stable isotopes. Journal of Pediatric Gastroenterology and Nutrition, 46(5), pp. 486-495. (doi: 10.1097/MPG.0b013e3181615b3a)
Bell, J., Preston, T. , Henderson, R., Strachan, F., Bron, J., Cooper, K. and Morrison, D.J. (2007) Discrimination of wild and cultured european sea bass (Dicentrarchus labrax) using chemical and isotopic analyses. Journal of Agricultural and Food Chemistry, 55, pp. 5934-5941. (doi: 10.1021/jf0704561)
Morrison, D. , Preston, T. , Bron, J.E., Hemderson, R.J., Cooper, K., Strachan, F. and Bell, J.G. (2007) Authenticating production origin of Gilthead Sea Bream (Sparus aurata) by chemical and isotopic fingerprinting. Lipids, 42(6), pp. 537-545. (doi: 10.1007/s11745-007-3055-3)
Dodson, B., Edwards, C., Mackay, W., Morrison, D., Preston, T. and Weaver, L. (2006) Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate? British Journal of Nutrition, 96, pp. 570-577. (doi: 10.1079/BJN20061853)
Morrison, D.J., Cooper, K., Waldron, S., Slater, C., Weaver, L.T. and Preston, T. (2004) A streamlined approach to the analysis of volatile fatty acids and its application to the measurement of whole-body flux. Rapid Communications in Mass Spectrometry, 18(21), pp. 2593-2600. (doi: 10.1002/rcm.1662)
Dodson, B., Morrison, D. , Preston, T. and Weaver, L. (2003) Gastrointestinal handling of glycosyl [C-13]ureides. European Journal of Clinical Nutrition, 57(8), pp. 1017-1024. (doi: 10.1038/sj.ejcn.1601637)
Morrison, D.J., Dodson, B., Preston, T. and Weaver, L.T. (2003) Gastrointestinal handling of glycosyl [13C]ureides. European Journal of Clinical Nutrition, 57(8), pp. 1017-1024. (doi: 10.1038/sj.ejcn.1601637)
Christian, M., Morrison, D., Dodson, B., Preston, T., Amarri, S., Franchini, F., Edwards, C. and Weaver, L. (2002) Measurement of oro-cecal transit time in young children using lactose [C-13] ureide requires further validation. Journal of Pediatric Gastroenterology and Nutrition, 34(5), pp. 570-571.
Christian, M.T., Amarri, S., Franchini, F., Preston, T., Morrison, D.J., Dodson, B., Edwards, C.A. and Weaver, L.T. (2002) Modeling C-13 breath curves to determine site and extent of starch digestion and fermentation in infants. Journal of Pediatric Gastroenterology and Nutrition, 34(2), pp. 158-164.
Edwards, C.A., Zavoshy, R., Khanna, S., Slater, C., Morrison, D.J., Preston, T. and Weaver, L.T. (2002) Production of C-13 labelled pea flour for use in human digestion and fermentation studies. Isotopes in Environmental and Health Studies, 38(3), pp. 139-147. (doi: 10.1080/10256010215130)
Wyse, C.A., Preston, T., Love, S., Morrison, D.J. , Cooper, J.M. and Yam, P.S. (2001) Use of the C-13-octanoic acid breath test for assessment of solid-phase gastric emptying in dogs. American Journal of Veterinary Research, 62(12), pp. 1939-1944. (doi: 10.2460/ajvr.2001.62.1939)
Wyse, C.A., Murphy, D.M., Preston, T. , Sutton, D.G. , Morrison, D.J. , Christley, R.M. and Love, S. (2001) The 13C-octanoic acid breath test for detection of effects of meal composition on the rate of solid-phase gastric emptying in ponies. Research in Veterinary Science, 71(1), pp. 81-3. (doi: 10.1053/rvsc.2001.0488)
Wyse, C.A., Murphy, D.M., Preston, T., Sutton, D.G.M., Morrison, D.J., Christley, R.M. and Love, S. (2001) The C-13-octanoic acid breath test for detection of effects of meal composition on the rate of solid-phase gastric emptying in ponies. Research in Veterinary Science, 71(1), pp. 81-83. (doi: 10.1053/rvsc.2001.0488)
Morrison, D.J., Dodson, B., Preston, T. and Weaver, L.T. (2001) Rapid quality control analysis of C-13-enriched substrate synthesis by isotope ratio mass spectrometry. Rapid Communications in Mass Spectrometry, 15(15), pp. 1279-1282. (doi: 10.1002/rcm.341)
Wyse, C.A., Murphy, D.M., Preston, T., Morrison, D.J. and Love, S. (2001) Assessment of the rate of solid-phase gastric emptying in ponies by means of the C-13-octanoic acid breath test: a preliminary study. Equine Veterinary Journal, 33(2), pp. 197-203.
Morrison, D.J. , Dodson, B., Slater, C. and Preston, T. (2000) C-13 natural abundance in the British diet: implications for C- 13 breath tests. Rapid Communications in Mass Spectrometry, 14(15), pp. 1321-1324. (doi: 10.1002/1097-0231(20000815)14:15<1321::AID-RCM946>3.0.CO;2-8)
Morrison, D. , Dodson, B. and Preston, T. (1999) Measurement of urinary total 13C and 13C urea by isotope ratio mass spectrometry after administration of lactose [13C]-Ureide. Rapid Communications in Mass Spectrometry, 13(13), pp. 1252-1256. (doi: 10.1002/(SICI)1097-0231(19990715)13:13<1252::AID-RCM565>3.0.CO;2-J)
Conference or Workshop Item
O'Brien, A. , Hallis, L. , Regnault, C., Morrison, D. , Blackburn, G., McKay, E. , Whitfield, P. and Lee, M. (2022) Soluble Organics Within the Newly Fallen Winchcombe Meteorite. 85th Annual Meeting of The Meteoritical Society, Glasgow, Scotland, 14-19 Aug 2022.
Patents
Imperial Innovations Limited and University of Glasgow (2014) Compounds and Their Effects on Appetite Control and Insulin Sensitivity. .
Grants
Targeting Appetite Regulation by Nutrient Delivery in the Gut. BBSRC Super Follow on Funding. 2012-2014.
Seeing the full spectrum: An integrated approach to characterization of Martian carbon. The Carnegie Trust for the Universities of Scotland. 2013-2014.
Next generation carbohydrates for appetite regulation. MRC. 2012-2016.
Emulsion structure: a novel mechanism of delivering fatty acids to regulate gut function and satiety. BBSRC. 2011-2014.
SCFA and satiety. Strategic Partnership Scheme, Scottish Government (RESAS). 2011-2016.
Drivers of propionate production in the colon. BBSRC. 2011-2015.
Increased propionate production in the colon is associated with reduced appetite, body weight and improved insulin sensitivity. BBSRC. 2009-2012.
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